Cancer cure found! This therapy will kill the tumor directly, with no need for the immune system.

Scientists made a revolutionary discovery in cancer treatment. They developed AUN bacteria therapy, which will directly destroy tumors without relying on the immune system. It was found to be safe in initial experiments.

In the world of cancer treatment, Japanese scientists have made a discovery that can change the direction of medical science in the coming years. Researchers at the Japan Advanced Institute of Science and Technology have developed a bacteria-based therapy that can directly destroy cancer tumors without the help of the immune system. It has been named AUN Bacteria Cancer Treatment. 

From a 150-year-old experiment to new discovery 

While doing research on cancer, doctors have been trying to make the immune system a weapon for years. In the late 19th century, Dr. William Coley first did this experiment, which is considered the basis of modern immunotherapy. Its biggest challenge has been that patients with weak immune systems are not able to benefit from this therapy. To overcome this shortcoming, JAIST scientists have developed a technology that does not depend on the immune system and targets cancer cells on its own. 

How AUN therapy works 

This therapy has been prepared by combining two different bacteria. 

• A-gyo- It reaches the tumor and directly attacks the cancer cells and their blood vessels.
• UN-gyo - This bacteria controls the activities of A-gyo so that instead of spreading the infection, it only affects the tumor. 

Interestingly, at the time of injection, the ratio of the two bacteria is different, about 3% A-gyo and 97% UN-gyo, but as soon as it reaches the tumor, the ratio changes to about 99% A-gyo. This change destroys the tumor faster while science also controls side effects. 

Big difference with immunotherapy 

Existing immunotherapies such as CART or checkpoint inhibitors are effective only when the body's immune system is active. In contrast, AUN therapy is completely immune independent. In the experiment, it has been found that the tumor was eliminated even in models with a weak immune system. Apart from this, serious side effects such as cytokine release syndrome did not appear. At the same time, bacteria continued to work in a controlled manner. That is, this therapy can become a new hope for those patients who have not got relief from the treatment so far. Professor Ejiro Miyako, who led the research, said that preparations are on to start its clinical trial in the coming years. The goal of the scientists is that this technology can reach the patients in the next 6 years. There is also a plan to create a startup for this.